Via the horse’s mouth: https://developer.salesforce.com/blogs/developer-relations/2014/01/python-and-the-force-com-rest-api-simple-simple-salesforce-example.html Third party: http://www.pocketsoap.com/beatbox/ (uses xmltramp, main parts of the 20.0 API is currently supported) https://pypi.python.org/pypi/simple-salesforce (Salesforce.com REST API client built for Python 2.6, 2.7, 3.2 and 3.3) https://code.google.com/p/salesforce-python-toolkit/ (Salesforce SOAP messaging, Enterprise and Partner WSDL formats, implements the Salesforce API 17.0 spec)